Basket 抗体 (pThr183, pTyr185)
BSK
适用: 大鼠
WB
宿主: 兔
Polyclonal
RB43487
unconjugated
(1 reference)-
- 抗原 See all Basket (BSK) products
- Basket (BSK)
- 抗原表位
- AA 157-189, pThr183, pTyr185
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Basket antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 预测反应
- C, M
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 157-189 amino acids from human.
- 克隆位点
- RB43487
- 亚型
- Ig Fraction
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- 应用备注
- WB: 1:500. WB: 1:500
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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: "Protective Effects and Mechanism of Meretrix meretrix Oligopeptides against Nonalcoholic Fatty Liver Disease." in: Marine drugs, Vol. 15, Issue 2, (2017) (PubMed).
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: "Protective Effects and Mechanism of Meretrix meretrix Oligopeptides against Nonalcoholic Fatty Liver Disease." in: Marine drugs, Vol. 15, Issue 2, (2017) (PubMed).
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- 抗原
- Basket (BSK)
- 别名
- JNK/SAPK (BSK 产品)
- 背景
- Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:< a href="http://www.uniprot.org/citations/22441692" target="_blank">22441692).
- 分子量
- 48139
- UniProt
- P45984
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