Basket 抗体 (pThr183, pTyr185)
This anti-Basket antibody is a 兔 多克隆 antibody detecting Basket in WB. Suitable for 大鼠. This Primary Antibody has been cited in 1 publication.
(1 reference)Quick Overview for Basket 抗体 (pThr183, pTyr185) (ABIN6241072)
抗原
Basket (BSK)
适用
大鼠
宿主
兔
克隆类型
多克隆
标记
This Basket antibody is un-conjugated
应用范围
Western Blotting (WB)
克隆位点
RB43487
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抗原表位
- AA 157-189, pThr183, pTyr185
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预测反应
- C, M
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 157-189 amino acids from human.
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亚型
- Ig Fraction
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应用备注
- WB: 1:500. WB: 1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "Protective Effects and Mechanism of Meretrix meretrix Oligopeptides against Nonalcoholic Fatty Liver Disease." in: Marine drugs, Vol. 15, Issue 2, (2017) (PubMed).
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: "Protective Effects and Mechanism of Meretrix meretrix Oligopeptides against Nonalcoholic Fatty Liver Disease." in: Marine drugs, Vol. 15, Issue 2, (2017) (PubMed).
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- Basket (BSK)
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别名
- JNK/SAPK
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背景
- Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:< a href="http://www.uniprot.org/citations/22441692" target="_blank">22441692).
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分子量
- 48139
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UniProt
- P45984
抗原
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