Annexin A2 抗体
Quick Overview for Annexin A2 抗体 (ABIN3022160)
抗原
See all Annexin A2 (ANXA2) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
纯化方法
- Affinity purification
-
免疫原
- Recombinant protein of human ANXA2
-
亚型
- IgG
-
-
anti-Annexin A2 (ANXA2) (AA 1-357) antibody
ANXA2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Annexin A2 (ANXA2) (AA 19-357) antibodyANXA2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1G7 unconjugated
anti-Annexin A2 (ANXA2) (AA 1-339) antibodyANXA2 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 3E8-B6 unconjugated
anti-Annexin A2 (ANXA2) (AA 19-49), (N-Term) antibodyANXA2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB15421 unconjugated
anti-Annexin A2 (ANXA2) (AA 2-339) antibodyANXA2 适用: 人 WB, ELISA, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Annexin A2 (ANXA2) (N-Term) antibodyKO Validated ANXA2 适用: 人 WB, IP, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Annexin A2 (ANXA2) (AA 1-339) antibodyANXA2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Annexin A2 (ANXA2) (AA 1-339) antibodyANXA2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Annexin A2 (ANXA2) (AA 1-339) antibodyANXA2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Annexin A2 (ANXA2) antibodyANXA2 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 1A1E1 unconjugated
-
-
应用备注
- Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid freeze / thaw cycles
-
储存条件
- -20 °C/-80 °C
-
-
- Annexin A2 (ANXA2)
-
别名
- ANXA2
-
背景
-
Annexin A2 (ANXA2), also known as lipocortin II or calpactin-1 heavy chain, is a 36 kDa member of the annexin superfamily that binds phospholipids and other proteins in a calcium-dependent manner via annexin repeats. Annexin A2 contains four such repeats through which it mediates protein-protein and protein-lipid interactions. It forms a constitutive heterotetramer with S100A10, acting as a bridge between the actin cytoskeleton, plasma membrane, and endocytotic vesicle machinery. Originally identified as a protein inhibitor of phospholipase A2, annexin A2 has subsequently been shown to interact with an array of protein and non-protein partners, including F-actin, spectrin, SNARE complexes, RNA, and virus particles. Annexin A2 has also been shown to have receptor-like activity and is detected on the surface of macrophages and vascular endothelial cells where it mediates macrophage activation and Factor Xa signaling, respectively. Upregulation of annexin A2 at the cell surface is thought to be modulated by phosphorylation at Tyr23 by Src. Interestingly, phosphorylation at Tyr23 has recently been shown to be required for cell surface expression of annexin A2 where it mediates motility, invasiveness, and overall metastatic potential of certain pancreatic cancer cells. Annexin A2 has also been shown to be heavily phosphorylated on serine residues in response to PKC activation via a pleiotropic mechanism. For a complete list of curated phosphorylation sites on annexin A2, please see PhosphoSitePlus® at www.phosphosite.org.
Synonyms: ANX2, ANX2L4, CAL1H, LIP2, LPC2, LPC2D, P36, PAP-IV -
基因ID
- 302
-
UniProt
- P07355
-
途径
- S100 Proteins
抗原
-
