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IGF2R 抗体 (PE)

IGF2R 适用: 人, 灵长类 FACS 宿主: 小鼠 Monoclonal MEM-238 PE
产品编号 ABIN616775
发货至: 中国
  • 抗原 See all IGF2R 抗体
    IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))
    适用
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    人, 灵长类
    宿主
    • 68
    • 22
    小鼠
    克隆类型
    • 67
    • 23
    单克隆
    标记
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    This IGF2R antibody is conjugated to PE
    应用范围
    • 35
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    Flow Cytometry (FACS)
    特异性
    Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 10e6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
    交叉反应 (详细)
    Species reactivity (tested):Human, Non-Human Primates
    免疫原
    Recombinant Vaccinia virus encoding CD222
    克隆位点
    MEM-238
    亚型
    IgG1
    Top Product
    Discover our top product IGF2R Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 缓冲液
    Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Dilute only prior to immediate use
    储存条件
    4 °C
    储存方法
    Store the antibody (undiluted) at 2-8 °C prior to opening. DO NOT FREEZE! Store reagent in the dark. Use subdued lighting during handling and incubation of cells prior to analysis.
  • 抗原
    IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))
    别名
    CD222 / IGF2R (IGF2R 产品)
    别名
    CD222 antibody, CIMPR antibody, M6P-R antibody, MPR1 antibody, MPRI antibody, AI661837 antibody, CI-MPR antibody, M6P/IGF2R antibody, Mpr300 antibody, mpri antibody, cd222 antibody, cimpr antibody, m6p-r antibody, insulin like growth factor 2 receptor antibody, insulin-like growth factor 2 receptor antibody, IGF2R antibody, Igf2r antibody, igf2r antibody
    背景
    CD222 (CIMPR, cation-independent mannose 6-phosphate receptor, IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10 % of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.Synonyms: 300 kDa mannose 6-phosphate receptor, CI Man-6-P receptor, CI-MPR, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, Late Endosome Marker, M6P/IGF2 receptor, M6P/IGF2R, M6PR, MPR 300, Mannose 6 Phosphate Receptor (Cation independent)
    基因ID
    3482
    NCBI登录号
    NP_000867
    UniProt
    P11717
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