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MVP 抗体 (CF®488A)

Name: MVP 抗体 (CF®488A)
SKU: ABIN6165369
Availability: OutOfStock

This anti-MVP antibody is a 小鼠单克隆 antibody detecting MVP in FACS, IF 和 IHC (f). Suitable for 人.

产品编号 ABIN6165369

发货至: 中国

Quick Overview for MVP 抗体 (CF®488A) (ABIN6165369)

抗原

See all MVP 抗体

MVP (Major Vault Protein (MVP))

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This MVP antibody is conjugated to CF®488A

应用范围

Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

克隆位点

1032

Discover our top product MVP Primary Antibody

原理

Mouse Monoclonal anti-Major Vault Protein (MVP) (1032), CF488A Conjugate

产品特性

This antibody recognizes a protein of 104 kDa-110 kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70 % of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

免疫原

Proteins precipitated from human breast cancer MCF-7 cells

亚型

IgG1 kappa
anti-Major Vault Protein (MVP) (AA 1-893) antibody
MVP 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2H3-1A6 unconjugated

anti-Major Vault Protein (MVP) (AA 2-272) antibody
MVP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Major Vault Protein (MVP) antibody
MVP 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Major Vault Protein (MVP) antibody
KO Validated MVP 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Major Vault Protein (MVP) (AA 2-259) antibody
MVP 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, ELISA, IF, IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated

anti-Major Vault Protein (MVP) (AA 88-180) antibody
MVP 适用: 人, 斑马鱼 FACS, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

anti-Major Vault Protein (MVP) antibody
MVP 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Major Vault Protein (MVP) antibody
MVP 适用: 人 FACS, IF 宿主: 小鼠 Monoclonal 1014 unconjugated

anti-Major Vault Protein (MVP) (C-Term) antibody
KO Validated MVP 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Major Vault Protein (MVP) (N-Term) antibody
MVP 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注
Immunohistology formalin-fixed 0.5-1 μg/mL
- Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA,  pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes
- Immunofluorescence 0.5-1 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Optimal dilution for a specific application should be determined by user
说明

MCF-7/HeLa, breast tumors

限制

仅限研究用
状态

Liquid

浓度

100 μg/mL

缓冲液

PBS/0.1 % BSA/0.05 % azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Protect from light
抗原

MVP (Major Vault Protein (MVP))

背景

Lung resistance-related protein (LRP), Major Vault Protein, MVP, VAULT1

分子量

104-110 kDa

基因ID

9961, 632177

UniProt

Q14764