ESAM 抗体 (AA 30-248)
Quick Overview for ESAM 抗体 (AA 30-248) (ABIN616014)
抗原
See all ESAM 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 30-248
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特异性
- This antibody will detect recombinant human soluble ESAM in Western blot and native ESAM in Immunoflourescence.
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交叉反应 （详细）
- Species reactivity (tested):Human
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纯化方法
- Protein A affinity chromatography
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免疫原
- Highly pure (>95%) recombinant human ESAM (Ile30-Ala248) derived from insect cells.
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anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 29-248) antibody
ESAM 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 21-120) antibodyESAM 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 1-390) antibodyESAM 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 30-248) antibodyESAM 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 1-390) antibodyESAM 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1G8 unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 1-390) antibodyESAM 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 1-390) antibodyESAM 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1E4 unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 30-248) antibodyESAM 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 31-390) antibodyESAM 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 31-251) antibodyESAM 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- Restore in sterile water to a concentration of 1.0 mg/mL.
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缓冲液
- PBS pH 7.4 w/o preservative
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- The lyophilized antibody is stable at room temperature for up to 1 month. Following reconstitution antibody can be stored at 2-8 °C for up to two weeks or (in aliquots) at -20 °C for longer.
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- ESAM (Endothelial Cell Adhesion Molecule (ESAM))
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别名
- ESAM
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背景
- Endothelial cellselective adhesion molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein that belongs to the JAM family of immunoglobulin superfamily molecules. Human ESAM is synthesized as a 390 amino acid (aa) protein composed of a 29 aa signal peptide, a 216 aa extracellular region, a putative 26 aa transmembrane segment, and a 119 aa cytoplasmic domain. The extracellular region contains one V-type and one C2-type Ig domain and is involved in hemophilic adhesion. In the cytoplasmic domain, there is a docking site for the multifunctional adaptor protein MAGI1. The extracellular region of human ESAM shows 90 % , 74 %, 69 % and 67 % aa identity with monkey, canine, mouse and rat extracellular ESAM, respectively. ESAM is expressed on endothelial cells, activated platelets and megakaryocytes, and can be found associated with cell to cell junctions. Whether ESAM is restricted to a particular junctional type is not clear. ESAM deficient mice have no defect in vascularization but do have reduced angiogenic potential. This may be due to a decreased migratory response to FGF2. Soluble ESAM is fused to a C-terminal His-tag (6x His).Synonyms: Endothelial cell-selective adhesion molecule
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基因ID
- 90952
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NCBI登录号
- NP_620411
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UniProt
- Q96AP7
抗原
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