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- 抗原 See all PDCD10 抗体
- PDCD10 (Programmed Cell Death 10 (PDCD10))
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抗原表位
- AA 1-212, N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PDCD10 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 特异性
- This antibody will detect recombinant Human CCM-3 in Western Blot and native CCM-3 in Immunohistochemistry.
- 交叉反应 （详细）
- Species reactivity (tested):Human.
- 纯化方法
- Affinity Chromatography with Immobilized Protein A
- 免疫原
- Highly pure (> 95%) recombinant Human CCM3, amino acids Met1-Ala212 derived from E.coli
- Top Product
- Discover our top product PDCD10 Primary Antibody
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anti-Programmed Cell Death 10 (PDCD10) antibody
PDCD10 适用: 人, 大鼠, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 10 (PDCD10) (AA 1-212) antibodyPDCD10 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 10 (PDCD10) (Internal Region) antibodyPDCD10 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 10 (PDCD10) (AA 145-212) antibodyPDCD10 适用: 大鼠 ELISA, IF (p), IF (cc), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 10 (PDCD10) (AA 103-212) antibodyPDCD10 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B11 unconjugated
anti-Programmed Cell Death 10 (PDCD10) (AA 1-212) antibodyKO Validated PDCD10 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 溶解方式
- Restore with sterile water to a concentration of 1.0 mg/mL.
- 缓冲液
- 5 mM PBS, pH 7.2 without preservatives or stabilizers
- 储存液
- Without preservative
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- The lyophilized antibody can be stored at RT for up to 1 month, or desiccated at -20 °C for longer. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- PDCD10 (Programmed Cell Death 10 (PDCD10))
- 别名
- PDCD10 (PDCD10 产品)
- 别名
- CCM3 antibody, TFAR15 antibody, 2410003B13Rik antibody, Ccm3 antibody, Tfa15 antibody, Tfar15 antibody, zgc:85629 antibody, ccm3a antibody, pdcd10 antibody, zgc:65826 antibody, programmed cell death 10 antibody, programmed cell death 10 S homeolog antibody, programmed cell death 10b antibody, programmed cell death 10a antibody, PDCD10 antibody, Pdcd10 antibody, pdcd10.S antibody, pdcd10b antibody, pdcd10a antibody
- 背景
- Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke. Mutations in CCM1, CCM2, or CCM3 lead to cerebral cavernous malformations, one of the most common hereditary vascular diseases of the brain. Endothelial cells within these lesions are the main disease compartments. Here, we show that adenoviral CCM3 expression inhibits endothelial cell migration, proliferation, and tube formation while down regulation of endogenous CCM3 results in increased formation of tube-like structures. Adenoviral CCM3 expression does not induce apoptosis under normal endothelial cell culture conditions but protects endothelial cells from staurosporine-induced cell death. Tyrosine kinase activity profiling suggests that CCM3 supports PDPK-1/Akt-mediated endothelial cell quiescence and survival (Schleider et al, Neurogenetics 12, 2011).Synonyms: CCM3, Cerebral cavernous malformations 3 protein, Programmed cell death protein 10, TF-1 cell apoptosis-related protein 15, TFAR15
- 基因ID
- 11235
- NCBI登录号
- NP_009148
- UniProt
- Q9BUL8
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