HSPG 抗体 (CF®488A)
Quick Overview for HSPG 抗体 (CF®488A) (ABIN6159593)
抗原
See all HSPG 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Rat Monoclonal anti-Heparan Sulfate Proteoglycan (A7L6), CF488A Conjugate
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产品特性
- This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment. Primary antibodies are available purified, or with a selection of fluorescent CF ® dyes and other labels. CF ® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF ®405S and CF ®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Murine EHS laminin preparation
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亚型
- IgG2a kappa
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anti-Heparan Sulphate Protoglycans (HSPG) (AA 19-144) antibody
HSPG 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Heparan Sulphate Protoglycans (HSPG) antibodyHSPG 适用: 人, Cow, 小鼠, 大鼠 WB, IHC, IP, IHC (p), ICC, IHC (fro) 宿主: 大鼠 Monoclonal unconjugated
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应用备注
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Immunohistology formalin-fixed 1-2 μg/mL
- Staining of formalin/paraffin tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min
- Immunofluorescence 0.5-1 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Optimal dilution for a specific application should be determined by user
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说明
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Breast carcinomas, squamous cell carcinomas.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 100 μg/mL
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缓冲液
- PBS/0.1 % BSA/0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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- HSPG (Heparan Sulphate Protoglycans (HSPG))
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别名
- Heparan Sulfate Proteoglycan
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背景
- Heparan sulfate proteoglycan of basement membrane, HSPG, Hspg2, LG3 peptide, Perlecan, PLC, SJS1
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分子量
- >400 kDa
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基因ID
- 3339, 562227
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UniProt
- P98160
抗原
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