alpha Defensin 1 抗体 (Internal Region)
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Quick Overview for alpha Defensin 1 抗体 (Internal Region) (ABIN615928)
抗原
See all alpha Defensin 1 (DEFA1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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序列
- C-DESLAPKHPG SRKN
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特异性
- This antibody is expected to equally recognize DEFA1 precursor and DEFA3 precursor.
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交叉反应 （详细）
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Species reactivity (tested):Human.
Also reacts to: Defensin alpha 3 -
纯化方法
- Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
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免疫原
- Peptide with sequence from the internal region of the protein sequence according to NP_004075.1, NP_005208.1. Genename: DEFA1/3
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anti-Defensin, alpha 1 (DEFA1) (AA 1-94) antibody
DEFA1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Defensin, alpha 1 (DEFA1) (AA 20-94) antibodyDEFA1 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Defensin, alpha 1 (DEFA1) (AA 20-93) antibodyDEFA1 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Defensin, alpha 1 (DEFA1) antibodyDEFA1 适用: 人, 小鼠 IHC, WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Defensin, alpha 1 (DEFA1) (AA 1-94) antibodyDEFA1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Defensin, alpha 1 (DEFA1) antibodyDEFA1 适用: 人 IHC, WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Defensin, alpha 1 (DEFA1) antibodyDEFA1 适用: 人 IHC, WB, ELISA, Neut, IHC (p) 宿主: 山羊 Polyclonal unconjugated
anti-Defensin, alpha 1 (DEFA1) antibodyDEFA1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Defensin, alpha 1 (DEFA1) (AA 28-62) antibodyDEFA1 适用: 人 WB 宿主: 兔 Polyclonal RB57879 unconjugated
anti-Defensin, alpha 1 (DEFA1) (Internal Region) antibodyVerified DEFA1 适用: 人 IHC, WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- alpha Defensin 1 (DEFA1) (Defensin, alpha 1 (DEFA1))
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别名
- Defensin alpha 1
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背景
- Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. It differs from defensin, alpha 3 by only one amino acid. Biological Functions: Various functions have been described for defensins. They are antibacterial, antifungal, chemotactic for monocytes, inhibitory for ACTH-induced corticosteroid synthesis and cytotoxic for cells. Defensins are inhibited by glucosaminoglycans (self protection for cells) and high concentrations of Ca2+ ions.Synonyms: DEF1, DEFA1, DEFA2, HNP-1, MRS, Neutrophil defensin 1
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基因ID
- 1667
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NCBI登录号
- NP_001035965
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UniProt
- P59665
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途径
- Cellular Response to Molecule of Bacterial Origin
抗原
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