Melanoma Marker 抗体 (CF®640R)
This CF®640R-conjugated 小鼠 单克隆 anti-Melanoma Marker antibody (Clone PNL2) specifically detects Melanoma Marker in IHC 和 IF. The antibody is reactive with 人, 犬 和 小鼠 samples.
产品编号 ABIN6157181
发货至:
中国
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中国
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北京 101111
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Quick Overview for Melanoma Marker 抗体 (CF®640R) (ABIN6157181)
抗原
Melanoma Marker
适用
人, 犬, 小鼠
宿主
小鼠
克隆类型
单克隆
标记
This Melanoma Marker antibody is conjugated to CF®640R
应用范围
Immunohistochemistry (IHC), Immunofluorescence (IF)
克隆位点
PNL2
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原理
- Mouse Monoclonal anti-Melanoma Marker (PNL2), CF640R Conjugate
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产品特性
- Anti-PNL2 is a novel monoclonal antibody, which has recently been introduced as an immunohistochemical reagent to stain melanocytes and tumors derived therefrom. The antigen recognized by PNL2 is different from Melan A and gp100. Its epitope is not destroyed by digestion with neuraminidase i.e. its epitope id not glycosylated. Anti-PNL2 may be most useful because of its high sensitivity for metastatic melanoma (87 % ), as opposed to 76 % for anti-HMB45 and 82 % for anti-MART-1. Anti-PNL2 labels intra-epidermal nevi while the dermal component of compound nevi are largely non-reactive with anti-PNL2. Antibodies against PNL2, MART-1 (Melan A) and HMB45 stain most clear cell sarcoma cells and a few cells in angio-myolipomas and lymphangioleiomyomatosis. Anti-PNL2 is a useful antibody for the identification of melanomas and clear cell sarcomas. Differential diagnosis is aided by the results from a panel of antibodies, including antibodies against HMB45, MART-1, tyrosinase, and MiTF. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. See the < a href="https://biotium.com/wp-content/uploads/2013/07/CF-dye-selection-guide.pdf" target="_blank" rel="noopener">CF® Dye Selection Guide for more information. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Melanocyte antigen
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亚型
- IgG1
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anti-Melanoma Marker antibody
适用: 人 IHC, IF 宿主: 小鼠 Monoclonal KBA-62 unconjugated
anti-Melanoma Marker antibody适用: 人, 犬, 小鼠 IHC, IF 宿主: 小鼠 Monoclonal PNL2 unconjugated
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应用备注
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Immunohistology (formalin)
- Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
- Immunofluorescence 0.5-1 μg/mL
- Optimal dilution for a specific application should be determined by user
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说明
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Melanoma
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 100 μg/mL
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缓冲液
- PBS/0.1 % BSA/0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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- Melanoma Marker
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背景
- Human Melanoma Associated Antigen, PNL2
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分子量
- Multiple (160 kDa, 100 kDa and <10 kDa)
抗原
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