IGFBPI 抗体
Quick Overview for IGFBPI 抗体 (ABIN615635)
抗原
See all IGFBPI 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Recognizes Human IGF-BP1
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纯化方法
- Affinity Chromatography employing an immobilized Human IGF-BP1
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免疫原
- Highly pure (>98%) recombinant Human IGF-BP1
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anti-Insulin-Like Growth Factor Binding Protein 1 (IGFBPI) (AA 36-235) antibody
IGFBPI 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 1 (IGFBPI) (AA 112-263) antibodyIGFBPI 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 1 (IGFBPI) (AA 112-262) antibodyIGFBPI 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 1 (IGFBPI) (AA 26-272) antibodyIGFBPI 适用: 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 1 (IGFBPI) antibodyIGFBPI 适用: 小鼠, 大鼠 WB, IHC (p), ELISA (Capture) 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 1 (IGFBPI) (AA 36-235) antibodyIGFBPI 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal D9 unconjugated
anti-Insulin-Like Growth Factor Binding Protein 1 (IGFBPI) (AA 26-259) antibodyIGFBPI 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 1 (IGFBPI) (AA 156-170) antibodyVerified IGFBPI 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 1 (IGFBPI) (AA 160-259) antibodyIGFBPI 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F9 unconjugated
anti-Insulin-Like Growth Factor Binding Protein 1 (IGFBPI) (C-Term) antibodyIGFBPI 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- Centrifuge vial prior to opening. Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS, pH 7.2 without preservatives.
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储存液
- Without preservative
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
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- IGFBPI (Insulin-Like Growth Factor Binding Protein 1 (IGFBPI))
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别名
- IGFBP1
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背景
- Insulin like growth factor binding protein 1 (IGFBP1) is a member of the superfamily of insulin like growth factor (IGF) binding proteins which include six high affinity IGF binding proteins (IGFBP) and at least four low affinity binding proteins referred to as IGFBP related proteins (IGFBPrP). The IGFBP members are cysteine rich proteins with conserved cysteine residues clustered in the amino terminal and the carboxy terminal regions of the molecule. The N terminal and C terminal regions are highly homologous among rat, human and bovine sequences. Contained within IGFBP1 and 2 is an integrin receptor recognition sequence (RGD) that is responsible for promoting cell migration by an IGF independent action. IGFBPs hold a central position in IGF ligand receptor interactions through influences on both the bioavailability and distribution of IGFs in the extracellular environment. IGFBPs will either inhibit or enhance the biological activities of IGF or act in an IGF independent manner. IGFBP1 is expressed in liver, decidua, and kidneys and is the major IGF binding protein in human amnionic fluid. In hepatocytes, IGFBP1 production is regulated at the transcriptional level due to the effects of insulin and corticosteriods. IGFBP1 is the major determinant of the level of free IGF in serum. The expression of IGFBP1 is inhibited by insulin, IGFI, and IGFII and is stimulated by glucocorticoids, thyroid hormone, and epidermal growth factor (EGF), indicating an endocrine function. IGFBP1 shows inhibitory actions on cell proliferation and differentiation, presumably by interfering with the interactions between IGF and the IGF receptor (IGFR).Synonyms: IBP-1, IBP1, IGF-binding protein 1, IGFBP-1, Insulin-like growth factor-binding protein 1, PP12, Placental protein 12
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基因ID
- 3484
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NCBI登录号
- NP_000587
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UniProt
- P08833
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途径
- Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Growth Factor Binding
抗原
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