PDIA4 抗体 (AA 623-638)
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Quick Overview for PDIA4 抗体 (AA 623-638) (ABIN615311)
抗原
See all PDIA4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 623-638
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特异性
- This antibody reacts to Protein Disulfide Isomerase Family A, Member 4 (PDIA4).
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交叉反应 (详细)
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Species reactivity (expected):Bovine, Canine, Guinea pig, Hamster, Human, Monkey, Rabbit, Rat.
Species reactivity (tested):Mouse. -
纯化方法
- Protein A Chromatography
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免疫原
- PDIA4 antibody was raised against a synthetic peptide based on the sequence of mouse ERp72 (residues 623-638) with a cysteine residue added and coupled to KLH.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- PBS containing 0.09 % azide and 50 % glycerol
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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- PDIA4 (Protein Disulfide Isomerase Family A, Member 4 (PDIA4))
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别名
- PDIA4
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背景
- Endoplasmic reticulum protein (ERp) 72 is a member of the protein disulfide isomerase (PDI) family1 that is localized to the endoplasmic reticulum. It contains three repeats of the thioredoxin-like regions that is postulated to represent three independently acting catalytic domains (CGHC) of PDI activity. ERp72 contains the sequence at its carboxyl terminus which serves as its ER retention signal. Together with other ER resident proteins such as BiP, GRP94, and PDI, they serve as the molecular chaperones for proper folding of newly translocated and glycolsylated proteins such as thyroglobulin (Tg) and human chorionic gonadotropin (hCG)-b. ERp72 expression is regulated by the level of misfolding proteins in the ER, as the amount of ERp72 increased in response to epithelial ischemia, a condition that perturbs the maturation of secretory proteins.Synonyms: ER marker, ER protein 70, ER protein 72, ERP70, ERP72, ERp-70, ERp-72, Endoplasmic reticulum resident protein 70, Endoplasmic reticulum resident protein 72, Protein Disulfide Isomerase, Protein disulfide-isomerase A4
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基因ID
- 9601
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NCBI登录号
- NP_004902
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UniProt
- P13667
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途径
- Thyroid Hormone Synthesis, Cell RedoxHomeostasis
抗原
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