Hepatocyte Specific Antigen 抗体 (CF®594)
Quick Overview for Hepatocyte Specific Antigen 抗体 (CF®594) (ABIN6152831)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Mouse Monoclonal anti-Hepatocyte-Specific (CPS1/1022), CF594 Conjugate
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产品特性
- This MAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant human CPS1 protein
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亚型
- IgG1
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anti-Hepatocyte Specific Antigen (HepPar-1) antibody
HepPar-1 适用: 人 IHC 宿主: 小鼠 Monoclonal MSVA-OCE5 unconjugated
anti-Hepatocyte Specific Antigen (HepPar-1) antibodyHepPar-1 适用: 人, 犬 IF, IHC, StM 宿主: 小鼠 Monoclonal HepPar1 unconjugated
anti-Hepatocyte Specific Antigen (HepPar-1) antibodyHepPar-1 适用: 人 Coat, ELISA 宿主: 小鼠 Monoclonal HSA98 unconjugated
anti-Hepatocyte Specific Antigen (HepPar-1) antibodyHepPar-1 适用: 人 IF, ICC 宿主: 小鼠 Monoclonal HSA133 unconjugated
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应用备注
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Immunohistology formalin-fixed 0.25-0.5 μg/mL
- Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes
- Immunofluorescence 0.5-1.0 μg/mL
- Optimal dilution for a specific application should be determined by user
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说明
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HeLa cells. Liver or Hepatocellular Carcinoma (HCC)
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 100 μg/mL
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缓冲液
- PBS/0.1 % BSA/0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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- Hepatocyte Specific Antigen (HepPar-1)
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别名
- Hepatocyte-Specific
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背景
- Carbamoyl-phosphate synthetase 1 (CPS1), Carbamoylphosphate synthetase 1, CPSase 1, CPSASE1
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分子量
- ~165 kDa
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基因ID
- 1373, 149252
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UniProt
- P31327
抗原
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