(1 reference)-
- 抗原 See all ZRANB3 products
- ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))
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抗原表位
- AA 818-1077
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ZRANB3 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- ITKQQTKQNC TKRYITKEDV AVASMDKVKN VGGHVRLITK ESRPRDPFTK KLLEDGACVP FLNPYTVQAD LTVKPSTSKG YLQAVDNEGN PLCLRCQQPT CQTKQACKAN SWDSRFCSLK CQEEFWIRSN NSYLRAKVFE TEHGVCQLCN VNAQELFLRL RDAPKSQRKN LLYATWTSKL PLEQLNEMIR NPGEGHFWQV DHIKPVYGGG GQCSLDNLQT LCTVCHKERT ARQAKERSQV RRQSLASKHG SDITRFLVKK
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Polyclonal Antibodies
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 818-1077 of human ZRANB3 (NP_001273497.1).
- 亚型
- IgG
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anti-Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3) (AA 370-624) antibody
ZRANB3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3) antibodyZRANB3 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB,1:1000 - 1:3000
- 说明
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HIGH QUALITY
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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-
: "Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe." in: Cell, Vol. 172, Issue 3, pp. 439-453.e14, (2019) (PubMed).
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: "Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe." in: Cell, Vol. 172, Issue 3, pp. 439-453.e14, (2019) (PubMed).
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- 抗原
- ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))
- 别名
- ZRANB3 (ZRANB3 产品)
- 别名
- 4933425L19Rik antibody, AH2 antibody, AI316834 antibody, C730006D09 antibody, zinc finger RANBP2-type containing 3 antibody, zinc finger, RAN-binding domain containing 3 antibody, ZRANB3 antibody, Zranb3 antibody
- 背景
- DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.,ZRANB3,4933425L19Rik,AH2,Epigenetics & Nuclear Signaling,ZRANB3
- 分子量
- 42 kDa/49 kDa/67 kDa/123 kDa
- 基因ID
- 84083
- UniProt
- Q5FWF4
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