Plays an important role in normal erythropoiesis (By similarity. It has a role in the differentiation of erythroid progenitors (By similarity. Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7.,TSPAN33,PEN,PEN.,TSPAN-33,Cell Biology & Developmental Biology,TSPAN33