THO Complex 5 抗体 (AA 150-370)
This anti-THO Complex 5 antibody is a 兔 多克隆 antibody detecting THO Complex 5 in WB. Suitable for 人.
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Quick Overview for THO Complex 5 抗体 (AA 150-370) (ABIN6149119)
抗原
See all THO Complex 5 (THOC5) 抗体
THO Complex 5 (THOC5)
适用
人
宿主
兔
克隆类型
多克隆
标记
This THO Complex 5 antibody is un-conjugated
应用范围
Western Blotting (WB)
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抗原表位
- AA 150-370
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序列
- FKSKHEEIDL VSLEEFYKEA PPDISKAEVT MGDPHQQTLA RLDWELEQRK RLAEKYRECL SNKEKILKEI EVKKEYLSSL QPRLNSIMQA SLPVQEYLFM PFDQAHKQYE TARHLPPPLY VLFVQATAYG QACDKTLSVA IEGSVDEAKA LFKPPEDSQD DESDSDAEEE QTTKRRRPTL GVQLDDKRKE MLKRHPLSVM LDLKCKDDSV LHLTFYYLMN L
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 150-370 of human THOC5 (NP_003669.4).
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亚型
- IgG
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anti-THO Complex 5 (THOC5) (AA 2-53) antibody
THOC5 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-THO Complex 5 (THOC5) (Internal Region) antibodyTHOC5 适用: 人 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- THO Complex 5 (THOC5)
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别名
- THOC5
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背景
- Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA, both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes, probably mediates association of the TREX and CFIm complexes., Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.,THOC5,C22orf19,Fmip,PK1.3,fSAP79,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,THOC5
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分子量
- 78 kDa
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基因ID
- 8563
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UniProt
- Q13769
抗原
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