SHARPIN 抗体 (AA 1-170)
Quick Overview for SHARPIN 抗体 (AA 1-170) (ABIN6147733)
抗原
See all SHARPIN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-170
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序列
- MAPPAGGAAA AASDLGSAAV LLAVHAAVRP LGAGPDAEAQ LRRLQLSADP ERPGRFRLEL LGAGPGAVNL EWPLESVSYT IRGPTQHELQ PPPGGPGTLS LHFLNPQEAQ RWAVLVRGAT VEGQNGSKSN SPPALGPEAC PVSLPSPPEA STLKGPPPEA DLPRSPGNLT
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human SHARPIN (NP_112236.3).
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亚型
- IgG
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anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 82-171) antibody
SHARPIN 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 1-326) antibodySHARPIN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 51-148) antibodySHARPIN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 301-350) antibodySHARPIN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (C-Term) antibodySHARPIN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (C-Term) antibodySHARPIN 适用: 人, 大鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IF,1:50 - 1:100
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说明
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HIGH QUALITY
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))
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别名
- SHARPIN
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背景
- Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.,SHARPIN,SIPL1,sharpin,Cell Biology & Developmental Biology,Ubiquitin,SHARPIN
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分子量
- 33 kDa/39 kDa
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基因ID
- 81858
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UniProt
- Q9H0F6
抗原
-
