METTL14 抗体 (AA 1-210)
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北京 101111
Quick Overview for METTL14 抗体 (AA 1-210) (ABIN6143759)
抗原
See all METTL14 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-210
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序列
- MDSRLQEIRE RQKLRRQLLA QQLGAESADS IGAVLNSKDE QREIAETRET CRASYDTSAP NAKRKYLDEG ETDEDKMEEY KDELEMQQDE ENLPYEEEIY KDSSTFLKGT QSLNPHNDYC QHFVDTGHRP QNFIRDVGLA DRFEEYPKLR ELIRLKDELI AKSNTPPMYL QADIEAFDIR ELTPKFDVIL LEPPLEEYYR ETGITANEKC
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human METTL14 (NP_066012.1).
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亚型
- IgG
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anti-Methyltransferase Like 14 (METTL14) (AA 2-36) antibody
METTL14 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB55130 unconjugated
anti-Methyltransferase Like 14 (METTL14) (AA 1-456) antibodyMETTL14 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Methyltransferase Like 14 (METTL14) (AA 21-120) antibodyMETTL14 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Methyltransferase Like 14 (METTL14) (AA 35-84) antibodyMETTL14 适用: 人, 小鼠, 大鼠, Cow, 马, 猴, Pig, 兔, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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: "N6-Methyladenosines Modulate A-to-I RNA Editing." in: Molecular cell, Vol. 69, Issue 1, pp. 126-135.e6, (2018) (PubMed).
: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." in: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).
: "Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation." in: Cell, Vol. 171, Issue 4, pp. 877-889.e17, (2017) (PubMed).
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: "N6-Methyladenosines Modulate A-to-I RNA Editing." in: Molecular cell, Vol. 69, Issue 1, pp. 126-135.e6, (2018) (PubMed).
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- METTL14 (Methyltransferase Like 14 (METTL14))
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别名
- METTL14
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背景
- The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6 position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A, which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity. In embryonic stem cells (ESCs, m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity.,METTL14,hMETTL14,Cell Biology & Developmental Biology,METTL14
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分子量
- 52 kDa
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基因ID
- 57721
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UniProt
- Q9HCE5
抗原
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