IL12RB1 抗体 (AA 25-305)
Quick Overview for IL12RB1 抗体 (AA 25-305) (ABIN6142300)
抗原
See all IL12RB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 25-305
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序列
- RTSECCFQDP PYPDADSGSA SGPRDLRCYR ISSDRYECSW QYEGPTAGVS HFLRCCLSSG RCCYFAAGSA TRLQFSDQAG VSVLYTVTLW VESWARNQTE KSPEVTLQLY NSVKYEPPLG DIKVSKLAGQ LRMEWETPDN QVGAEVQFRH RTPSSPWKLG DCGPQDDDTE SCLCPLEMNV AQEFQLRRRQ LGSQGSSWSK WSSPVCVPPE NPPQPQVRFS VEQLGQDGRR RLTLKEQPTQ LELPEGCQGL APGTEVTYRL QLHMLSCPCK AKATRTLHLG K
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交叉反应
- 人, 小鼠
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产品特性
- Polyclonal Antibodies
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 25-305 of human IL12RB1 (NP_714912.1).
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亚型
- IgG
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应用备注
- WB,1:500 - 1:2000
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说明
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HIGH QUALITY
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
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别名
- IL12RB1
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背景
- The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.,IL12RB1,CD212,IL-12R-BETA1,IL12RB,IMD30,Epigenetics & Nuclear Signaling,Immunology & Inflammation,CD markers,Cytokines,Interleukins,Cell Intrinsic Innate Immunity Signaling Pathway,IL12RB1
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分子量
- 42 kDa/72 kDa/73 kDa
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基因ID
- 3594
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UniProt
- P42701
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途径
- JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
抗原
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