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F13A1 抗体 (AA 600-732)

This anti-F13A1 antibody is a 兔 多克隆 antibody detecting F13A1 in WB. Suitable for 人.
产品编号 ABIN6140402
发货至: 中国

Quick Overview for F13A1 抗体 (AA 600-732) (ABIN6140402)

抗原

See all F13A1 抗体
F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))

适用

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宿主

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克隆类型

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多克隆

标记

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This F13A1 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    AA 600-732

    序列

    LEQASLHFFV TARINETRDV LAKQKSTVLT IPEIIIKVRG TQVVGSDMTV TVEFTNPLKE TLRNVWVHLD GPGVTRPMKK MFREIRPNST VQWEEVCRPW VSGHRKLIAS MSSDSLRHVY GELDVQIQRR PSM

    交叉反应

    人, 小鼠, 大鼠

    产品特性

    Polyclonal Antibodies

    纯化方法

    Affinity purification

    免疫原

    Recombinant fusion protein containing a sequence corresponding to amino acids 600-732 of human F13A1 (NP_000120.2).

    亚型

    IgG
  • 应用备注

    WB,1:500 - 1:2000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))

    别名

    F13A1

    背景

    This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.,F13A1,F13A,Cardiovascular,Blood,Coagulation,Serum Proteins,F13A1

    分子量

    83 kDa

    基因ID

    2162

    UniProt

    P00488
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