F13A1 抗体 (AA 600-732)
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北京 101111
Quick Overview for F13A1 抗体 (AA 600-732) (ABIN6140402)
抗原
See all F13A1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 600-732
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序列
- LEQASLHFFV TARINETRDV LAKQKSTVLT IPEIIIKVRG TQVVGSDMTV TVEFTNPLKE TLRNVWVHLD GPGVTRPMKK MFREIRPNST VQWEEVCRPW VSGHRKLIAS MSSDSLRHVY GELDVQIQRR PSM
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 600-732 of human F13A1 (NP_000120.2).
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亚型
- IgG
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应用备注
- WB,1:500 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))
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别名
- F13A1
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背景
- This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.,F13A1,F13A,Cardiovascular,Blood,Coagulation,Serum Proteins,F13A1
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分子量
- 83 kDa
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基因ID
- 2162
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UniProt
- P00488
抗原
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