Cathepsin F 抗体 (AA 270-484)
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Quick Overview for Cathepsin F 抗体 (AA 270-484) (ABIN6139225)
抗原
See all Cathepsin F (CTSF) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 270-484
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序列
- LAPPEWDWRS KGAVTKVKDQ GMCGSCWAFS VTGNVEGQWF LNQGTLLSLS EQELLDCDKM DKACMGGLPS NAYSAIKNLG GLETEDDYSY QGHMQSCNFS AEKAKVYIND SVELSQNEQK LAAWLAKRGP ISVAINAFGM QFYRHGISRP LRPLCSPWLI DHAVLLVGYG NRSDVPFWAI KNSWGTDWGE KGYYYLHRGS GACGVNTMAS SAVVD
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交叉反应
- 人, 小鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 270-484 of human CTSF (NP_003784.2).
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亚型
- IgG
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- Cathepsin F (CTSF)
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别名
- CTSF
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背景
- Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.,CTSF,CATSF,CLN13,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,CTSF
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分子量
- 53 kDa
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基因ID
- 8722
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UniProt
- Q9UBX1
抗原
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