CNOT1 抗体 (AA 2137-2376)
This 兔 多克隆 anti-CNOT1 antibody specifically detects CNOT1 in WB 和 IF. The antibody is reactive with 人 samples.
产品编号 ABIN6138777
发货至:
中国
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Contact Info
Our Local Distributor
中国
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北京 101111
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Quick Overview for CNOT1 抗体 (AA 2137-2376) (ABIN6138777)
抗原
See all CNOT1 抗体
CNOT1
(CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
适用
人
宿主
兔
克隆类型
多克隆
标记
This CNOT1 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunofluorescence (IF)
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抗原表位
- AA 2137-2376
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序列
- PRNMRLPDPF TPNLKVDMLS EINIAPRILT NFTGVMPPQF KKDLDSYLKT RSPVTFLSDL RSNLQVSNEP GNRYNLQLIN ALVLYVGTQA IAHIHNKGST PSMSTITHSA HMDIFQNLAV DLDTEGRYLF LNAIANQLRY PNSHTHYFSC TMLYLFAEAN TEAIQEQITR VLLERLIVNR PHPWGLLITF IELIKNPAFK FWNHEFVHCA PEIEKLFQSV AQCCMGQKQA QQVMEGTGAS
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交叉反应
- 人, 小鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 2137-2376 of human CNOT1 (NP_057368.3).
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亚型
- IgG
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anti-CCR4-NOT Transcription Complex, Subunit 1 (CNOT1) (AA 604-867) antibody
CNOT1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:200 - 1:2000,IF,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
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别名
- CNOT1
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背景
- Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES cell identity.,CNOT1,AD-005,CDC39,NOT1,NOT1H,Epigenetics & Nuclear Signaling,RNA Binding,CNOT1
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分子量
- 173 kDa/241 kDa/266 kDa
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基因ID
- 23019
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UniProt
- A5YKK6
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途径
- Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance
抗原
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