Antizyme Inhibitor 1 抗体 (AA 289-448)
Quick Overview for Antizyme Inhibitor 1 抗体 (AA 289-448) (ABIN6137388)
抗原
See all Antizyme Inhibitor 1 (AZIN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 289-448
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序列
- AKKVVENDKF PSGVEKTGSD EPAFMYYMND GVYGSFASKL SEDLNTIPEV HKKYKEDEPL FTSSLWGPSC DELDQIVESC LLPELNVGDW LIFDNMGADS FHEPSAFNDF QRPAIYYMMS FSDWYEMQDA GITSDSMMKN FFFVPSCIQL SQEDSFSAEA
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 289-448 of human AZIN1 (NP_056962.2).
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亚型
- IgG
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anti-Antizyme Inhibitor 1 (AZIN1) (AA 5-290) antibody
AZIN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Antizyme Inhibitor 1 (AZIN1) (AA 101-400) antibodyAZIN1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Antizyme Inhibitor 1 (AZIN1) (AA 1-280) antibodyAZIN1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Antizyme Inhibitor 1 (AZIN1) (AA 1-448) antibodyAZIN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Antizyme Inhibitor 1 (AZIN1) (AA 339-447) antibodyAZIN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F11 unconjugated
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antizyme Inhibitor 1 (AZIN1)
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别名
- AZIN1
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背景
- The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine, however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene.,AZIN1,AZI,AZI1,AZIA1,OAZI,OAZIN,ODC1L,Signal Transduction,Endocrine & Metabolism,Amino acid metabolism,AZIN1
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分子量
- 49 kDa
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基因ID
- 51582
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UniProt
- O14977
抗原
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