ATR 抗体 (pSer428)
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- 抗原 See all ATR 抗体
- ATR (ATR serine/threonine kinase (ATR))
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抗原表位
- pSer428
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ATR antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 序列
- GISPK
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Phosphorylated Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- A synthetic phosphorylated peptide around S428 of human ATR (NP_001175.2).
- 亚型
- IgG
- Top Product
- Discover our top product ATR Primary Antibody
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- 应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
- 说明
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HIGH QUALITY
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- ATR (ATR serine/threonine kinase (ATR))
- 别名
- ATR (ATR 产品)
- 别名
- FCTCS antibody, FRP1 antibody, MEC1 antibody, SCKL antibody, SCKL1 antibody, ATR serine/threonine kinase antibody, ataxia telangiectasia and Rad3 related antibody, ATR antibody, Atr antibody
- 背景
- The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.,ATR,FCTCS,FRP1,MEC1,SCKL,SCKL1,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Phosphorylation,DNA Damage & Repair,Cancer,Tumor suppressors,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Cell Cycle,G1/S Checkpoint,G2/M DNA Damage Checkpoint,Protein phosphorylation,ATR
- 分子量
- 294 kDa/297 kDa/301 kDa
- 基因ID
- 545
- UniProt
- Q13535
- 途径
- Positive Regulation of Response to DNA Damage Stimulus
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