CD8B 抗体
(9 references)Quick Overview for CD8B 抗体 (ABIN609653)
抗原
See all CD8B 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Rt CD8b Purified
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特异性
- The mouse monoclonal antibody 341 (also known as 34.1) recognizes rat CD8b, the 32-34 kDa beta chain of the CD8 coreceptor (extracellular epitope), expressed on T cell subsets and some other cell types, such as macrophages.
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交叉反应 （详细）
- Rat
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- CD8 positive Wistar rat splenic T cell hybridomas
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亚型
- IgG1 kappa
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anti-CD8b Molecule (CD8B) (AA 51-150) antibody
CD8B 适用: 人 WB, ELISA, IHC (fro), ICC, IF (cc), IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD8b Molecule (CD8B) antibody (FITC)CD8B 适用: 大鼠 FACS 宿主: 小鼠 Monoclonal 341 FITC
anti-CD8b Molecule (CD8B) antibody (PE)CD8B 适用: 大鼠 FACS 宿主: 小鼠 Monoclonal 341 PE
anti-CD8b Molecule (CD8B) (AA 22-170) antibodyCD8B 适用: 人 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD8b Molecule (CD8B) (AA 22-170) antibodyCD8B 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD8b Molecule (CD8B) (AA 1-243) antibodyCD8B 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-CD8b Molecule (CD8B) antibodyCD8B 适用: 大鼠 FACS, WB, IP, IHC (fro), Func 宿主: 小鼠 Monoclonal 341 unconjugated
anti-CD8b Molecule (CD8B) antibody (PE)CD8B 适用: Cow, 绵羊, 山羊, Water Buffalo FACS 宿主: 小鼠 Monoclonal CC58 PE
anti-CD8b Molecule (CD8B) antibody (PE)CD8B 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal H35-17-2 PE
anti-CD8b Molecule (CD8B) (AA 22-170) antibodyCD8B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Flow cytometry: Recommended dilution: 1.5 μg/mL.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "Prognostic impact of ZAP-70 expression in chronic lymphocytic leukemia: mean fluorescence intensity T/B ratio versus percentage of positive cells." in: Journal of translational medicine, Vol. 8, pp. 23, (2010) (PubMed).
: "Significant change in ZAP-70 expression during the course of chronic lymphocytic leukemia." in: European journal of haematology, Vol. 84, Issue 6, pp. 513-7, (2010) (PubMed).
: "Recent thymic origin, differentiation, and turnover of regulatory T cells." in: Journal of leukocyte biology, Vol. 84, Issue 5, pp. 1287-97, (2008) (PubMed).
: "Regulation of CD8 expression in mast cells by exogenous or endogenous nitric oxide." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 10, pp. 5935-9, (2001) (PubMed).
: "Islet cell membrane antigens activate diabetogenic CD4+ T-cells in the BB/Wor rat." in: Diabetes, Vol. 48, Issue 5, pp. 975-82, (1999) (PubMed).
: "Mast cells express novel CD8 molecules that selectively modulate mediator secretion." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 11, pp. 6265-72, (1998) (PubMed).
: "Negative regulation of rat natural killer cell activity by major histocompatibility complex class I recognition." in: European journal of immunology, Vol. 26, Issue 11, pp. 2582-6, (1997) (PubMed).
: "A novel CD8 molecule expressed by alveolar and peritoneal macrophages stimulates nitric oxide production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 4, pp. 1833-40, (1997) (PubMed).
: "Differential thymus dependence of rat CD8 isoform expression." in: European journal of immunology, Vol. 22, Issue 11, pp. 2841-8, (1992) (PubMed).
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: "Prognostic impact of ZAP-70 expression in chronic lymphocytic leukemia: mean fluorescence intensity T/B ratio versus percentage of positive cells." in: Journal of translational medicine, Vol. 8, pp. 23, (2010) (PubMed).
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- CD8B (CD8b Molecule (CD8B))
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别名
- CD8b
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背景
- CD8b molecule,The CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages, mast cells, and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.,Ly-3, Ly-C, Lyt-3
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基因ID
- 926
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UniProt
- P10966
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途径
- TCR Signaling
抗原
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