TERT 抗体 (Ser824)
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北京 101111
Quick Overview for TERT 抗体 (Ser824) (ABIN5958627)
抗原
See all TERT 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Ser824
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特异性
- CMM9,DKCA2,DKCB4,EST2,HEST2,htert,hTRT,PFBMFT1,TCS1,Telomerase associated protein 2,Telomerase catalytic subunit,Telomerase reverse transcriptase,Telomerase-associated protein 2,Telomere Reverse Transcriptase,TERT,TERT,TP2,TRT
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纯化方法
- Affinity purification
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免疫原
- Synthesized peptide derived from human TERT around the non-phosphorylation site of Ser824.
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亚型
- IgG
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应用备注
- WB 1:500-1:2000, ELISA 1:20000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- TERT (Telomerase Reverse Transcriptase (TERT))
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别名
- TERT
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背景
- Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified, the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
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分子量
- 127kDa
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基因ID
- 7015
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UniProt
- O14746
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途径
- Telomere Maintenance
抗原
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