PPM1F 抗体 (AA 1-454)
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北京 101111
Quick Overview for PPM1F 抗体 (AA 1-454) (ABIN5776247)
抗原
See all PPM1F 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-454
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原理
- Human PPM1F antibody
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纯化方法
- Purified
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免疫原
- Recombinant human PPM1F (1-454aa) purified from E. coli
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亚型
- IgG1 kappa
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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- PPM1F (Protein Phosphatase 1F (PP2C Domain Containing) (PPM1F))
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别名
- PPM1F
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背景
- PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
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NCBI登录号
- NP_055449
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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