PKM 抗体 (AA 1-531)
Quick Overview for PKM 抗体 (AA 1-531) (ABIN5776015)
抗原
See all PKM 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-531
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免疫原
- Recombinant human PKM2 (1-531aa) purified from E.coli
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亚型
- IgG1 kappa
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.
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- PKM (Pyruvate Kinase M1/2 (PKM))
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别名
- PKM
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背景
- PKM2 (pyruvate kinase M2), its association with phospho-tyrosine (pTyr) motifs, enables cells to use predominantly aerobic glycolysis instead of oxidative phosphorylation. Also PKM2 suggest that this change benefits cancer cells by enabling them to redirect glycolytic metabolites away from oxidation and energy production and, instead, toward anabolic processes and biosynthesis. PKM2-mediated generation of the aerobic glycolytic phenotype, although wasteful in terms of glucose consumption and waste generation, could provide a variety of advantages for cancerous cells. In addition nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death.
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NCBI登录号
- NP_002645
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途径
- Warburg Effect
抗原
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