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MMP3 抗体 (AA 317-327)

This anti-MMP3 antibody is a 兔 单克隆 antibody detecting MMP3 in IHC (p). Suitable for 人.
产品编号 ABIN5708006
发货至: 中国

Quick Overview for MMP3 抗体 (AA 317-327) (ABIN5708006)

抗原

See all MMP3 抗体
MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))

适用

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宿主

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克隆类型

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单克隆

标记

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This MMP3 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

MMP3-1994R
  • 抗原表位

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    AA 317-327

    纯化方法

    Purified

    纯度

    Protein A affinity chromatography

    免疫原

    Amino acids 317-327 were used as the immunogen for the recombinant MMP3 antibody.

    亚型

    IgG kappa
  • 应用备注

    Optimal dilution of the recombinant MMP3 antibody should be determined by the researcher.

    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-0.1 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

    限制

    仅限研究用
  • 缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    Store the recombinant MMP3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))

    别名

    MMP3 / Matrix Metalloproteinase 3

    背景

    The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP3, MMP10 and MMP11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP3 activation of procollagenase can occur via two pathways. Direct activation by MMP3 is slow and activation by MMP3 in conjunction with tissue or plasma proteinases is rapid. MMP10 is expressed in small intestine, and at lower levels in lung and heart. MMP11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.
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