ISR-alpha 抗体
Quick Overview for ISR-alpha 抗体 (ABIN5707973)
抗原
See all ISR-alpha 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Purified
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纯度
- Protein A affinity chromatography
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免疫原
- A recombinant partial protein from the extracellular region of the protein was used as the immunogen for the recombinant Insulin Receptor alpha antibody.
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亚型
- IgG kappa
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anti-Insulin Receptor alpha (ISR-alpha) antibody
ISR-alpha 适用: 人, 大鼠, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor alpha (ISR-alpha) (AA 701-760) antibodyISR-alpha 适用: 人, 大鼠 IF (cc), IF (p), WB, FACS, IHC (p), ELISA, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor alpha (ISR-alpha) (AA 51-150) antibodyISR-alpha 适用: 人, 大鼠 IF (cc), IF (p), IHC (p), ELISA, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor alpha (ISR-alpha) antibodyISR-alpha 适用: 人 Crys 宿主: 兔 Chimeric Fab 83-7 unconjugated Recombinant Antibody
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应用备注
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Optimal dilution of the recombinant Insulin Receptor alpha antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1) -
限制
- 仅限研究用
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the recombinant Insulin Receptor alpha antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- ISR-alpha (Insulin Receptor alpha (ISR-alpha))
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别名
- Insulin Receptor alpha
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背景
- The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular β, subunit and an extracellular α, subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.
抗原
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