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Filaggrin 抗体 (AA 198-288)

This anti-Filaggrin antibody is a 兔 单克隆 antibody detecting Filaggrin in IHC (p). Suitable for 人.
产品编号 ABIN5707859
发货至: 中国

Quick Overview for Filaggrin 抗体 (AA 198-288) (ABIN5707859)

抗原

See all Filaggrin (FLG) 抗体
Filaggrin (FLG)

适用

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宿主

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克隆类型

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单克隆

标记

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This Filaggrin antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

FLG-1957R
  • 抗原表位

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    AA 198-288

    纯化方法

    Purified

    纯度

    Protein G affinity chromatography

    免疫原

    Amino acids 198-288 of human Filaggrin were used as the immunogen for this recombinant FLG antibody.

    亚型

    IgG kappa
  • 应用备注

    Optimal dilution of the recombinant FLG antibody should be determined by the researcher.

    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format : incubate for 30 min at RT (1)

    限制

    仅限研究用
  • 缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    Store the recombinant FLG antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    Filaggrin (FLG)

    别名

    Filaggrin

    背景

    Filaggrin (FLG) is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple Filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional Filaggrin molecules. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

    途径

    Sensory Perception of Sound, Stem Cell Maintenance
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