IFIH1 抗体 (AA 1-210)
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北京 101111
Quick Overview for IFIH1 抗体 (AA 1-210) (ABIN5703110)
抗原
See all IFIH1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-210
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原理
- IFIH1 antibody
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免疫原
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Immunogen sequence: 1-210aa
Immunogen: interferon induced with helicase C domain 1
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亚型
- IgG
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anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (AA 1-205) antibody
IFIH1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (N-Term) antibodyVerified IFIH1 适用: 人, 猴 WB, ELISA, IHC, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (C-Term) antibodyIFIH1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (C-Term) antibodyIFIH1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (AA 700-1025) antibodyIFIH1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) antibodyIFIH1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (AA 612-661) antibodyIFIH1 适用: 人, 小鼠, 大鼠, Cow, 马, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) antibodyKD Validated IFIH1 适用: 人 WB 宿主: 兔 Monoclonal 24GB6085 unconjugated Recombinant Antibody
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (AA 1-221) antibodyIFIH1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (AA 928-1023) antibodyIFIH1 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3F6 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))
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别名
- IFIH1
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背景
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Synonyms: Interferon-induced helicase C domain-containing protein 1|Clinically amyopathic dermatomyositis autoantigen 140 kDa (CADM-140 autoantigen)|Helicase with 2 CARD domains (Helicard)|Interferon-induced with helicase C domain protein 1|Melanoma differentiation-associated protein 5 (MDA-5)|Murabutide down-regulated protein|RIG-I-like receptor 2 (RLR-2)|RNA helicase-DEAD box protein 116|IFIH1|MDA5|RH116
Background: Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA(>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein(MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons(IFNs), IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus(EMCV) and mengo encephalomyocarditis virus(ENMG). Can also detect other viruses such as dengue virus(DENV), west Nile virus(WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L(RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.
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分子量
- 117-125 kDa
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基因ID
- 64135
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UniProt
- Q9BYX4
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途径
- Activation of Innate immune Response
抗原
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