BCR 抗体
Quick Overview for BCR 抗体 (ABIN5697146)
抗原
See all BCR 抗体适用
宿主
克隆类型
标记
应用范围
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免疫原
- breakpoint cluster region
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Y79 cells were subjected to SDS PAGE followed by western blot with FNab00854(BCR antibody) at dilution of 1:1000
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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有效期
- 12 months
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- BCR (Breakpoint Cluster Region (BCR))
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别名
- BCR
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背景
- Synonyms:BCR1, D22S11 Background:A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
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分子量
- 150-160 kDa
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基因ID
- 613
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UniProt
- P11274
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途径
- Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling
抗原
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