GALE 抗体 (AA 1-340)
Quick Overview for GALE 抗体 (AA 1-340) (ABIN5693266)
抗原
See all GALE 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-340
-
原理
- Anti-GALE Antibody Picoband®
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
产品特性
- Anti-GALE Antibody Picoband® (ABIN5693266). Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
免疫原
- E. coli-derived human GALE recombinant protein (Position: M1-N340).
-
亚型
- IgG
-
-
anti-UDP-Galactose-4-Epimerase (GALE) antibody
GALE 适用: 人, 大鼠, 犬, 猴 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1C4 unconjugated
anti-UDP-Galactose-4-Epimerase (GALE) (AA 1-348) antibodyGALE 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-UDP-Galactose-4-Epimerase (GALE) (AA 142-171) antibodyGALE 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB21189 unconjugated
anti-UDP-Galactose-4-Epimerase (GALE) (AA 1-348) antibodyGALE 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-UDP-Galactose-4-Epimerase (GALE) (AA 1-348) antibodyGALE 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-UDP-Galactose-4-Epimerase (GALE) (AA 129-348) antibodyGALE 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-UDP-Galactose-4-Epimerase (GALE) (AA 201-250) antibodyGALE 适用: 人, 犬, Cow, Pig, 兔, 马, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-UDP-Galactose-4-Epimerase (GALE) (N-Term) antibodyGALE 适用: 人, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-UDP-Galactose-4-Epimerase (GALE) (N-Term) antibodyGALE 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-UDP-Galactose-4-Epimerase (GALE) antibodyGALE 适用: 人 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Maceratesi, P., Daude, N., Dallapiccola, B., Novelli, G., Allen, R., Okano, Y., Reichardt, J.Human UDP-galactose 4-prime epimerase (GALE) gene and identification of five missense mutations in patients with epimerase-deficiency galactosemia. Molec. Genet. Metab. 63: 26-30, 1998. 2. Thoden JB, Wohlers TM, Fridovich-Keil JL, Holden HM (May 2001). "Human UDP-galactose 4-epimerase. Accommodation of UDP-N-acetylglucosamine within the active site". J. Biol. Chem. 276 (18): 15131-6. -
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
-
-
- GALE (UDP-Galactose-4-Epimerase (GALE))
-
别名
- GALE
-
背景
-
Synonyms: UDP-glucose 4-epimerase
Tissue Specificity: Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas.
Background: The enzyme UDP-glucose 4-epimerase, also known as UDP-galactose 4-epimerase or GALE, is a homodimeric epimerase found in bacterial, fungal, plant, and mammalian cells. This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
-
分子量
- 38 kDa
-
基因ID
- 2582
-
UniProt
- Q14376
-
途径
- Response to Water Deprivation, Cellular Glucan Metabolic Process
抗原
-
