ASXL1 抗体
Quick Overview for ASXL1 抗体 (ABIN5693162)
抗原
See all ASXL1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Anti-ASXL1 Antibody Picoband®
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序列
- KKERTWAEAA RLVLENYSDA PMTPKQILQV IEAE
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-ASXL1 Antibody Picoband® (ABIN5693162). Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human ASXL1, identical to the related mouse and rat sequences.
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亚型
- IgG
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anti-Additional Sex Combs Like 1 (ASXL1) (AA 1-84) antibody
ASXL1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6E2 unconjugated
anti-Additional Sex Combs Like 1 (ASXL1) (AA 521-549) antibodyASXL1 适用: 小鼠 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB24070 unconjugated
anti-Additional Sex Combs Like 1 (ASXL1) (AA 521-549) antibodyASXL1 适用: 人, 小鼠 WB, FACS, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Additional Sex Combs Like 1 (ASXL1) antibodyASXL1 适用: 人 DB 宿主: 小鼠 Monoclonal 2049C2a unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x106 cells
1. "Entrez Gene: ASXL1 additional sex combs like 1 (Drosophila)". 2. Fisher CL, Berger J, Randazzo F, Brock HW (Mar 2003). "A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11". Gene. 306: 115-26. 3. Park, U.-H., Yoon, S. K., Park, T., Kim, E.-J., Um, S.-J. Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor gamma. J. Biol. Chem. 286: 1354-1363, 2011. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- ASXL1 (Additional Sex Combs Like 1 (ASXL1))
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别名
- ASXL1
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背景
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Synonyms: Putative Polycomb group protein ASXL1, Additional sex combs-like protein 1, ASXL1, KIAA0978
Tissue Specificity: Widely expressed at low level. Expressed in heart, brain, skeletal muscle, placenta, pancreas, spleen, prostate, small intestine, colon, peripheral blood, leukocytes, bone marrow and fetal liver. Highly expressed in testes.
Background: Putative Polycomb group protein ASXL1 is a protein that in humans is encoded by the ASXL1 gene. This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.
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分子量
- 165 kDa
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基因ID
- 171023
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途径
- Retinoic Acid Receptor Signaling Pathway
抗原
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