AGRP 抗体 (AA 82-131)
Quick Overview for AGRP 抗体 (AA 82-131) (ABIN5693160)
抗原
See all AGRP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 82-131
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原理
- Anti-AGRP Antibody
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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产品特性
- Anti-AGRP Antibody Picoband® (ABIN5693160). Tested in ELISA, IHC applications. This antibody reacts with Human, Mouse, Rat.
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免疫原
- E. coli-derived mouse AGRP recombinant protein (Position: S82-T131).
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亚型
- IgG
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS (Oct 1997). "Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein". Science. 278 (5335): 135-8. 2. Shutter JR, Graham M, Kinsey AC, Scully S, Lüthy R, Stark KL (Mar 1997). "Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice". Genes & Development.11 (5): 593-602. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- AGRP (Agouti Related Protein Homolog (Mouse) (AGRP))
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别名
- Agrp
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背景
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Synonyms: Agouti-related protein, Agrp, Agrt, Art
Tissue Specificity: Expressed in arcuate nucleus and median eminence, adrenal gland (medulla), hypothalamus, testis, and lung.
Background: Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the brain by the AgRP/NPY neuron. In humans, the agouti-related peptide is encoded by the AGRP gene. This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
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分子量
- 49 kDa
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基因ID
- 11604
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UniProt
- P56473
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途径
- Feeding Behaviour, Photoperiodism
抗原
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