DYNLT1 抗体 (AA 1-80)
Quick Overview for DYNLT1 抗体 (AA 1-80) (ABIN5693148)
抗原
See all DYNLT1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-80
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原理
- Anti-DYNLT1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-DYNLT1 Antibody Picoband® (ABIN5693148). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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免疫原
- E. coli-derived human DYNLT1 recombinant protein (Position: M1-A80).
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亚型
- IgG
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anti-Dynein, Light Chain, Tctex-Type 1 (DYNLT1) (AA 1-113) antibody
DYNLT1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Dynein, Light Chain, Tctex-Type 1 (DYNLT1) (N-Term) antibodyDYNLT1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL
Immunocytochemistry/Immunofluorescence, 5 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x106 cells
ELISA, 0.1-0.5 μg/mL
1. Chuang, J.-Z., Yeh, T.-Y., Bollati, F., Conde, C., Canavosio, F., Caceres, A., Sung, C.-H. The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth. Dev. Cell 9: 75-86, 2005. 2. Machado, R. D., Rudarakanchana, N., Atkinson, C., Flanagan, J. A., Harrison, R., Morrell, N. W., Trembath, R. C. Functional interaction between BMPR-II and Tctex-1, a light chain of dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. Hum. Molec. Genet. 12: 3277-3286, 2003. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- DYNLT1 (Dynein, Light Chain, Tctex-Type 1 (DYNLT1))
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别名
- DYNLT1
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背景
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Synonyms: Dynein light chain Tctex-type 1, Protein CW-1, T-complex testis-specific protein 1 homolog, DYNLT1, TCTEL1, TCTEX-1, TCTEX1
Tissue Specificity: Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level).
Background: Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene. This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms.
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分子量
- 15 kDa
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基因ID
- 6993
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UniProt
- P63172
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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