TPMT 抗体 (AA 1-245)
Quick Overview for TPMT 抗体 (AA 1-245) (ABIN5693135)
抗原
See all TPMT 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-245
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原理
- Anti-TPMT Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-TPMT Antibody Picoband® (ABIN5693135). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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免疫原
- E. coli-derived human TPMT recombinant protein (Position: M1-K245).
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亚型
- IgG
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anti-Thiopurine S-Methyltransferase (TPMT) (AA 26-227) antibody
TPMT 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thiopurine S-Methyltransferase (TPMT) (AA 1-245) antibodyTPMT 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1B5 unconjugated
anti-Thiopurine S-Methyltransferase (TPMT) antibodyTPMT 适用: 人, 犬 WB, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 4C1 unconjugated
anti-Thiopurine S-Methyltransferase (TPMT) (AA 4-244) antibodyTPMT 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Thiopurine S-Methyltransferase (TPMT) (AA 1-245) antibodyTPMT 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Thiopurine S-Methyltransferase (TPMT) (AA 1-245) antibodyTPMT 适用: 人 WB, ELISA, IF, ICC 宿主: 小鼠 Monoclonal AT2E7 unconjugated
anti-Thiopurine S-Methyltransferase (TPMT) (N-Term) antibodyTPMT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Thiopurine S-Methyltransferase (TPMT) antibodyTPMT 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Thiopurine S-Methyltransferase (TPMT) antibodyTPMT 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Thiopurine S-Methyltransferase (TPMT) antibodyTPMT 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Lee D, Szumlanski C, Houtman J, Honchel R, Rojas K, Overhauser J, Wieben ED, Weinshilboum RM (March 1995). "Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1". Drug Metab. Dispos. 23 (3): 398-405. 2. Weinshilboum RM, Sladek SL (1980). "Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity". American Journal of Human Genetics. 32 (5): 651-662. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- TPMT (Thiopurine S-Methyltransferase (TPMT))
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别名
- TPMT
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背景
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Synonyms: Thiopurine S-methyltransferase, Thiopurine methyltransferase, TPMT
Tissue Specificity: Expressed in natural killer (NK) cells, CD8 (+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).
Background: Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene. This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
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分子量
- 28 kDa
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基因ID
- 7172
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UniProt
- P51580
抗原
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