CRLF2 抗体 (AA 26-231)
Quick Overview for CRLF2 抗体 (AA 26-231) (ABIN5693100)
抗原
See all CRLF2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 26-231
-
原理
- Anti-CRLF2 Antibody Picoband®
-
交叉反应 (详细)
- No cross-reactivity with other proteins.
-
产品特性
- Anti-CRLF2 Antibody Picoband® (ABIN5693100). Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
免疫原
- E. coli-derived human CRLF2 recombinant protein (Position: A26-K231).
-
亚型
- IgG
-
-
-
-
应用备注
-
Western blot, 0.1-0.5 μg/mL
ELISA (Cap), 1-5 μg/mL
1. "Entrez Gene: CRLF2 cytokine receptor-like factor 2". 2. Tonozuka Y, Fujio K, Sugiyama T, Nosaka T, Hirai M, Kitamura T (Jul 2001). "Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR". Cytogenet Cell Genet. 93 (1-2): 23-5. 3. Zhang W, Wang J, Wang Q, Chen G, Zhang J, Chen T, Wan T, Zhang Y, Cao X (Mar 2001). "Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes". Biochem Biophys Res Commun. 281 (4): 878-83. -
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
-
-
- CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))
-
别名
- CRLF2
-
背景
-
Synonyms: Cytokine receptor-like factor 2, Cytokine receptor-like 2, IL-XR, Thymic stromal lymphopoietin protein receptor, TSLP receptor, CRLF2, CRL2, ILXR, TSLPR
Tissue Specificity: Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells.
Background: Cytokine receptor-like factor 2 is a protein that in humans is encoded by the CRLF2 gene. This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.
-
分子量
- 65-75 kDa
-
基因ID
- 64109
抗原
-