ABCC8 抗体
Quick Overview for ABCC8 抗体 (ABIN5693055)
抗原
See all ABCC8 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Anti-SUR1/ABCC8 Antibody Picoband®
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序列
- TIQREGTLKD FQRSECQLFE HWKTLMNRQD QELEKETVTE RKA
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-SUR1/ABCC8 Antibody Picoband® (ABIN5693055). Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human SUR1, which shares 97.7% amino acid (aa) sequence identity with both mouse and rat SUR1.
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亚型
- IgG
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anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 679-929) antibody
ABCC8 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibodyABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 unconjugated
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibody (HRP)ABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 HRP
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibody (FITC)ABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 FITC
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibody (Biotin)ABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 Biotin
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibody (PE)ABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 PE
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibody (PerCP)ABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 PerCP
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibody (APC)ABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 APC
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibody (Atto 488)ABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 Atto 488
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 1548-1582) antibody (Atto 594)ABCC8 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S289-16 Atto 594
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应用备注
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Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL
Immunocytochemistry, 0.5-1 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x106 cells1. "Entrez Gene: ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8". 2. Glaser B, Chiu KC, Anker R, Nestorowicz A, Landau H, Ben-Bassat H, Shlomai Z, Kaiser N, Thornton PS, Stanley CA, et al. (Nov 1994). "Familial hyperinsulinism maps to chromosome 11p14-15.1, 30 cM centromeric to the insulin gene". Nat Genet. 7 (2): 185-8. 3. Thomas PM, Cote GJ, Wohllk N, Haddad B, Mathew PM, Rabl W, Aguilar-Bryan L, Gagel RF, Bryan J (May 1995). "Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy". Science. 268 (5209): 426-9. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
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别名
- ABCC8
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背景
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Synonyms: ATP-binding cassette sub-family C member 8, Sulfonylurea receptor 1, ABCC8, HRINS, SUR, SUR1
Background: ATP-binding cassette transporter sub-family C member 8 is a protein that in humans is encoded by the ABCC8 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene.
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分子量
- 177 kDa
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基因ID
- 6833
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UniProt
- Q09428
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途径
- Negative Regulation of Hormone Secretion
抗原
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