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Retinoblastoma Binding Protein 4 抗体 (C-Term)

This anti-Retinoblastoma Binding Protein 4 antibody is a 小鼠 单克隆 antibody detecting Retinoblastoma Binding Protein 4 in WB 和 IHC. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN5692929
发货至: 中国

Quick Overview for Retinoblastoma Binding Protein 4 抗体 (C-Term) (ABIN5692929)

抗原

See all Retinoblastoma Binding Protein 4 (RBBP4) 抗体
Retinoblastoma Binding Protein 4 (RBBP4)

适用

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人, 小鼠, 大鼠

宿主

  • 60
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小鼠

克隆类型

  • 50
  • 19
单克隆

标记

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This Retinoblastoma Binding Protein 4 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC)

克隆位点

9F3
  • 抗原表位

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    AA 395-425, C-Term

    原理

    Anti-RbAp48 RBBP4 Antibody Picoband® (monoclonal, 9F3)

    序列

    EDNIMQVWQM AENIYNDEDP EGSVDPEGQG S

    交叉反应 (详细)

    No cross-reactivity with other proteins.

    产品特性

    Anti-RbAp48 RBBP4 Antibody Picoband® (monoclonal, 9F3) (ABIN5692929). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    免疫原

    A synthetic peptide corresponding to a sequence at the C-terminus of human RbAp48, identical to the related mouse sequence.

    亚型

    IgG1
  • 应用备注

    Western blot, 0.1-0.5 μg/mL
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
    1. "Entrez Gene: RBBP4 retinoblastoma-binding protein 4". 2. Barak O, Lazzaro MA, Lane WS, Speicher DW, Picketts DJ, Shiekhattar R (November 2003). "Isolation of human NURF: a regulator of Engrailed gene expression". EMBO J 22 (22): 6089-100. 3. Qian YW, Wang YC, Hollingsworth RE Jr, Jones D, Ling N, Lee EY (September 1993). "A retinoblastoma-binding protein related to a negative regulator of Ras in yeast". Nature 364 (6438): 648-52.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • 抗原

    Retinoblastoma Binding Protein 4 (RBBP4)

    别名

    RBBP4

    背景

    Synonyms: Histone-binding protein RBBP4, Chromatin assembly factor 1 subunit C, CAF-1 subunit C, Chromatin assembly factor I p48 subunit, CAF-I 48 kDa subunit, CAF-I p48, Nucleosome-remodeling factor subunit RBAP48, Retinoblastoma-binding protein 4, RBBP-4, Retinoblastoma-binding protein p48, RBBP4, RBAP48

    Background: Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a protein that in humans is encoded by the RBBP4 gene. This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. And it is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind ly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene.

    分子量

    55 kDa

    基因ID

    5928

    UniProt

    Q09028

    途径

    Cell Division Cycle, Mitotic G1-G1/S Phases, Stem Cell Maintenance, Chromatin Binding, Protein targeting to Nucleus
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