CSTB 抗体 (AA 1-98) (DyLight 488)
Quick Overview for CSTB 抗体 (AA 1-98) (DyLight 488) (ABIN5692839)
抗原
See all CSTB 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
 - AA 1-98
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原理
 - Anti-Human Stefin B DyLight® 488 conjugated CSTB Antibody(monoclonal, 2B6)
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交叉反应 (详细)
 - No cross-reactivity with other proteins.
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产品特性
 - Anti-Human Stefin B DyLight® 488 conjugated CSTB Antibody (monoclonal, 2B6) (ABIN5692840)-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.
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免疫原
 - E. coli-derived human Stefin B recombinant protein (Position: M1-F98). Human Stefin B shares 78.6 % amino acid (aa) sequence identity with both mouse and rat Stefin B.
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亚型
 - IgG1
 
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应用备注
 - Flow Cytometry (Fixed), 1-3 μg/1x106 cells1. Alakurtti, K., Weber, E., Rinne, R., Theil, G., de Haan, G.-J., Lindhout, D., Salmikangas, P., Saukko, P., Lahtinen, U., Lehesjoki, A.-E. Loss of lysosomal association of cystatin B proteins representing progressive myoclonus epilepsy, EPM1, mutations. Europ. J. Hum. Genet. 13: 208-215, 2005. Note: Erratum: Europ. J. Hum. Genet. 13: 264 only, 2005. 2. Antonarakis, S. Personal Communication. Geneva, Switzerland 4/8/1997. 3. Bespalova, I. N., Adkins, S., Pranzatelli, M., Burmeister, M. Novel cystatin B mutation and diagnostic PCR assay in an Unverricht-Lundborg progressive myoclonus epilepsy patient. Am. J. Med. Genet. 74: 467-471, 1997.
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限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - Lot specific
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缓冲液
 - Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
 - Sodium azide
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注意事项
 - This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
 - -20 °C
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储存方法
 - At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
 
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- CSTB (Cystatin B (Stefin B) (CSTB))
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别名
 - CSTB
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背景
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Synonyms: Cystatin-B, CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CSTB, CST6, STFB
Background: Cystatin B (CSTB), also called STFB, is a small protein that is a member of the superfamily of cysteine protease inhibitors. It has been isolated from human spleen and liver and its amino acid sequence has been fully determined. The cystatin B gene is located on 21q22.3. It is widely distributed and is localized mostly intracellularly, but has been found extracellularly. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Its role is thought to be as a protector against the proteinases leaking from lysosomes. A cystatin B multiprotein complex might have a specific cerebellar function, and that the loss of this function might contribute to the etiopathogenesis of EPM1. Upon differentiation to myotubes, CSTB becomes excluded from the nucleus and lysosomes, suggesting that the subcellular distribution of CSTB is dependent on the differentiation status of the cell.
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分子量
 - 39 kDa
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基因ID
 - 1476
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UniProt
 - P04080
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途径
 - Response to Water Deprivation
 
抗原
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