Cullin 5 抗体 (AA 2-105)
Quick Overview for Cullin 5 抗体 (AA 2-105) (ABIN5692832)
抗原
See all Cullin 5 (CUL5) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2-105
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原理
- Anti-Cullin 5/CUL5 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Cullin 5/CUL5 Antibody Picoband® (ABIN5692832). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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免疫原
- E. coli-derived human Cullin 5 recombinant protein (Position: A2-D105).
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亚型
- IgG
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anti-Cullin 5 (CUL5) (AA 1-300) antibody
CUL5 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cullin 5 (CUL5) antibodyCUL5 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cullin 5 (CUL5) antibodyCUL5 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cullin 5 (CUL5) (AA 1-300) antibodyCUL5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cullin 5 (CUL5) (AA 747-774), (C-Term) antibodyCUL5 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB17926 unconjugated
anti-Cullin 5 (CUL5) antibodyCUL5 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Cullin 5 (CUL5) (AA 701-780) antibodyCUL5 适用: 人 ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cullin 5 (CUL5) (AA 1-100) antibodyCUL5 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Cullin 5 (CUL5) (AA 1-50) antibodyCUL5 适用: 人, 小鼠, 大鼠, 斑马鱼, Cow, 马, 非洲爪蟾, Pig WB, IHC, IF, IHC (p), IP 宿主: 兔 Polyclonal unconjugated
anti-Cullin 5 (CUL5) (C-Term) antibodyCUL5 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Feng L, Allen NS, Simo S, Cooper JA (November 2007). "Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development". Genes Dev. 21 (21): 2717-30. 2. Petroski MD, Deshaies RJ (2005). "Function and regulation of cullin-RING E3 ligases". Nature Reviews Molecular Cell Biology. 6 (1): 9-21. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Cullin 5 (CUL5)
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别名
- CUL5
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背景
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Synonyms: Cullin-5, CUL-5, Vasopressin-activated calcium-mobilizing receptor 1, VACM-1, CUL5, VACM1
Tissue Specificity: Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in the bipolar, horizontal and amacrine cells in the inner nuclear layer (INL), extending to the inner plexiform layer (IPL) and though the ganglion cell layer (GCL) and into the nerve fiber layer (NFL) (at protein level).
Background: Cullin-5 is a protein that in humans is encoded by the CUL5 gene. Cul5 inhibits cellular proliferation, potentially through its involvement in the SOCS/ BC-box/ eloBC/ cul5/ RING E3 ligase complex, which functions as part of the ubiquitin system for protein degradation. One study have shown that Cul5 plays a role in Reelin signaling cascade, participating in the DAB1 degradation and thus ensuring the negative feedback mechanism of Reelin signaling during corticogenesis.
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分子量
- 91 kDa
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基因ID
- 8065
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UniProt
- Q93034
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途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
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