Bestrophin 1 抗体
Quick Overview for Bestrophin 1 抗体 (ABIN5692801)
抗原
See all Bestrophin 1 (BEST1) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Anti-Bestrophin/BEST1 Antibody Picoband®
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序列
- RFIYRLALTE EQQLMFEKLT LYCD
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Bestrophin/BEST1 Antibody Picoband® (ABIN5692801). Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human Bestrophin, which shares 62.5% amino acid (aa) sequence identity with mouse Bestrophin.
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亚型
- IgG
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anti-Bestrophin 1 (BEST1) (AA 200-300) antibody
BEST1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Bestrophin 1 (BEST1) antibodyBEST1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Bestrophin 1 (BEST1) antibodyBEST1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Bestrophin 1 (BEST1) (AA 1-604) antibodyBEST1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Bestrophin 1 (BEST1) (AA 259-270), (Extracellular) antibodyBEST1 适用: 小鼠 WB, IHC, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Bestrophin 1 (BEST1) (AA 361-460) antibodyBEST1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C2 unconjugated
anti-Bestrophin 1 (BEST1) (AA 376-585) antibodyBEST1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Bestrophin 1 (BEST1) antibodyBEST1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Bestrophin 1 (BEST1) (AA 292-585) antibodyBEST1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL
Immunocytochemistry, 0.5-1 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x106 cells
1. "Entrez Gene: BEST1 bestrophin 1". 2. Johnson AA, Guziewicz KE, Lee CJ, Kalathur RC, Pulido JS, Marmorstein LY, Marmorstein AD (January 2017). "Bestrophin 1 and retinal disease". review. Progress in Retinal and Eye Research. 58: 45-69. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Bestrophin 1 (BEST1)
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别名
- BEST1
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背景
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Synonyms: Bestrophin-1, TU15B, Vitelliform macular dystrophy protein 2, BEST1, VMD2
Tissue Specificity: Predominantly expressed in the basolateral membrane of the retinal pigment epithelium.
Background: Bestrophin-1 (Best1) is a protein that, in humans, is encoded by the BEST1 gene. This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
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分子量
- 68 kDa
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基因ID
- 7439
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UniProt
- O76090
抗原
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