Bestrophin 1 抗体
Quick Overview for Bestrophin 1 抗体 (ABIN5692801)
抗原
See all Bestrophin 1 (BEST1) 抗体适用
宿主
克隆类型
标记
应用范围
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                                            原理
- Anti-Bestrophin/BEST1 Antibody Picoband®
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                                            序列
- RFIYRLALTE EQQLMFEKLT LYCD
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                                            交叉反应 (详细)
- No cross-reactivity with other proteins.
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                                            产品特性
- Anti-Bestrophin/BEST1 Antibody Picoband® (ABIN5692801). Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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                                            免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human Bestrophin, which shares 62.5% amino acid (aa) sequence identity with mouse Bestrophin.
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                                            亚型
- IgG
 
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                                            应用备注
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                        Western blot, 0.1-0.5 μg/mL
 Immunohistochemistry (Frozen Section), 0.5-1 μg/mL
 Immunocytochemistry, 0.5-1 μg/mL
 Flow Cytometry (Fixed), 1-3 μg/1x106 cells
 1. "Entrez Gene: BEST1 bestrophin 1". 2. Johnson AA, Guziewicz KE, Lee CJ, Kalathur RC, Pulido JS, Marmorstein LY, Marmorstein AD (January 2017). "Bestrophin 1 and retinal disease". review. Progress in Retinal and Eye Research. 58: 45-69.
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                                            限制
- 仅限研究用
 
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                                            状态
- Lyophilized
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                                            溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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                                            浓度
- 500 μg/mL
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                                            缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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                                            储存液
- Sodium azide
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                                            注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            储存条件
- 4 °C,-20 °C
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                                            储存方法
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                        Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. 
 It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
 
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    - Bestrophin 1 (BEST1)
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                                            别名
- BEST1
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                                            背景
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                        Synonyms: Bestrophin-1, TU15B, Vitelliform macular dystrophy protein 2, BEST1, VMD2 Tissue Specificity: Predominantly expressed in the basolateral membrane of the retinal pigment epithelium. Background: Bestrophin-1 (Best1) is a protein that, in humans, is encoded by the BEST1 gene. This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms. 
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                                            分子量
- 68 kDa
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                                            基因ID
- 7439
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                                            UniProt
- O76090
 抗原
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