Beclin 2 抗体 (AA 30-80)
This anti-Beclin 2 antibody is a 兔 多克隆 antibody detecting Beclin 2 in WB, IHC (p), ELISA 和 IF. Suitable for 人.
Quick Overview for Beclin 2 抗体 (AA 30-80) (ABIN5689901)
抗原
See all Beclin 2 (BECN1L1) 抗体
Beclin 2 (BECN1L1)
(Beclin-1-Like Protein 1 (BECN1L1))
适用
人
宿主
兔
克隆类型
多克隆
标记
This Beclin 2 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunofluorescence (IF)
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抗原表位
- AA 30-80
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特异性
- Beclin 2 antibody is human specific. At least two isoforms of Beclin 2 are known to exist, this antibody will only detect the longer isoform. Beclin 2 antibody is predicted to not cross-react with Beclin 1.
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纯化方法
- Beclin 2 antibody is affinity chromatography purified via peptide column.
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免疫原
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Beclin 2 antibody was raised against a 16 amino acid peptide near the amino terminus of human Beclin 2.
The immunogen is located within amino acids 30 - 80 of Beclin 2. -
亚型
- IgG
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应用备注
- Beclin 2 antibody can be used for detection of Beclin 2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Beclin 2 antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Beclin 2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- Beclin 2 (BECN1L1) (Beclin-1-Like Protein 1 (BECN1L1))
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别名
- Beclin 2
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背景
- Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells (1,2). Beclin 2 is a mammalian specific homolog of the autophagy protein Beclin 1 (3). Like Beclin 1, Beclin 2 interacts with Bcl-2 and class III PI3K complex components. However, Beclin 2 functions in an additional lysosomal degradation pathway and is required for ligand-induced endolysosomal degradation of several G protein-coupled receptors (3). Beclin 2 is also required for agonist-induced lysosome-mediated degradation of EGFR in lung cancer cells, suggesting that it may also play a role in regulating other intracellular signaling pathways (4).
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分子量
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Predicted: 47 kDa
Observed: 55 kDa -
基因ID
- 441925
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NCBI登录号
- NP_001277622
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UniProt
- A8MW95
抗原
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