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Tyrosine Hydroxylase 抗体 (AA 29-33)

This anti-Tyrosine Hydroxylase antibody is a 兔 多克隆 antibody detecting Tyrosine Hydroxylase in WB. Suitable for 大鼠 和 小鼠.
产品编号 ABIN5689619
发货至: 中国
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Quick Overview for Tyrosine Hydroxylase 抗体 (AA 29-33) (ABIN5689619)

抗原

See all Tyrosine Hydroxylase (TH) 抗体
Tyrosine Hydroxylase (TH)

适用

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大鼠, 小鼠

宿主

  • 140
  • 33
  • 7
  • 5
  • 2

克隆类型

  • 125
  • 62
多克隆

标记

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This Tyrosine Hydroxylase antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    AA 29-33

    特异性

    This antibody detects endogenous levels of total Tyrosine Hydroxylase protein.

    纯化方法

    Antibodies were purified by affinity-chromatography using epitope-specific peptide.

    免疫原

    Tyrosine Hydroxylase (Ab-31) antibody was raised against a peptide sequence around aa.29~33 (V-T-S-P-R) derived from Mouse Tyrosine Hydroxylase.
  • 应用备注

    Western Blot: 1:500~1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store antibody at -20°C for up to one year.
  • 抗原

    Tyrosine Hydroxylase (TH)

    别名

    Tyrosine Hydroxylase

    背景

    Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the neurotransmitter dopamine and other catecholamines. TH functions as a tetramer, with each subunit composed of a regulatory and catalytic domain, and exists in several different isoforms . This enzyme is required for embryonic development since TH knockout mice die before or at birth . Levels of transcription, translation and posttranslational modification regulate TH activity. The amino-terminal regulatory domain contains three serine residues: Ser9, Ser31 and Ser40. Phosphorylation at Ser40 by PKA positively regulates the catalytic activity of TH . Phosphorylation at Ser31 by CDK5 also increases the catalytic activity of TH through stabilization of TH protein levels.

    分子量

    55 - 60 kDa

    基因ID

    7054

    NCBI登录号

    NP_954986

    途径

    Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour
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