CBL 抗体 (AA 698-702)
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Quick Overview for CBL 抗体 (AA 698-702) (ABIN5689531)
抗原
See all CBL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 698-702
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特异性
- This antibody detects endogenous level of total c-Cbl protein.
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纯化方法
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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免疫原
- c-Cbl (Ab-700) antibody was raised against a peptide sequence around aa. 698~702 (T-E-Y-M-T) derived from Human c-Cbl.
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应用备注
- Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store antibody at -20°C for up to one year.
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- CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
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别名
- c Cbl
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背景
- Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.
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分子量
- 120 kDa
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基因ID
- 867
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NCBI登录号
- NP_005179
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UniProt
- P22681
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途径
- TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals
抗原
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