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TAZ 抗体 (AA 386-390)

This anti-TAZ antibody is a 兔 多克隆 antibody detecting TAZ in WB. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN5689355
发货至: 中国

Quick Overview for TAZ 抗体 (AA 386-390) (ABIN5689355)

抗原

See all TAZ 抗体
TAZ (Tafazzin (TAZ))

适用

  • 75
  • 31
  • 31
  • 3
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  • 2
  • 2
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  • 2
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 70
  • 8
  • 1
  • 1
  • 1

克隆类型

  • 72
  • 9
多克隆

标记

  • 37
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  • 2
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  • 2
  • 1
  • 1
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This TAZ antibody is un-conjugated

应用范围

  • 66
  • 28
  • 26
  • 26
  • 16
  • 16
  • 9
  • 8
  • 8
  • 6
  • 4
  • 1
  • 1
  • 1
Western Blotting (WB)
  • 抗原表位

    • 16
    • 15
    • 8
    • 5
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    • 4
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    • 2
    • 2
    • 2
    • 1
    • 1
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    • 1
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    AA 386-390

    特异性

    This antibody detects endogenous level of total TAZ protein.

    纯化方法

    Antibodies were purified by affinity-chromatography using epitope-specific peptide.

    免疫原

    TAZ antibody was raised against a peptide sequence around aa.386~390 (V-E-S-A-L) derived from Human TAZ.
  • 应用备注

    Western Blot: 1:500~1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store antibody at -20°C for up to one year.
  • 抗原

    TAZ (Tafazzin (TAZ))

    别名

    TAZ

    背景

    Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

    分子量

    49 kDa

    基因ID

    25937

    NCBI登录号

    NP_001161750

    UniProt

    Q9GZV5
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