AIMP1 antibody is human, mouse and rat reactive. At least two isoforms of AIMP1 are known to exist, this antibody will recognize both isoforms. AIMP1 antibody is predicted to not cross-react with AIMP2.
纯化方法
AIMP1 antibody is affinity chromatography purified via peptide column.
免疫原
AIMP1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human AIMP1.
The immunogen is located within amino acids 240 - 290 of AIMP1.
AIMP1 antibody can be used for detection of AIMP1 by Western blot at 1 μ,g/mL.
限制
仅限研究用
状态
Liquid
浓度
1 mg/mL
缓冲液
AIMP1 antibody is supplied in PBS containing 0.02 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C,-20 °C
储存方法
AIMP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
抗原
AIMP1
(Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1))
别名
AIMP1
背景
AIMP1 (Endothelial monocyte-activating polypeptide II, EMAP2) is a proinflammatory cytokine for monocytes and granulocytes (1). It is specifically induced by apoptosis and is involved in the control of angiogenesis, inflammation, and wound healing (1,2). AIMP1 was identified as one of three auxiliary factors of the mammalian aminoacyl tRNA synthetase (ARS) complex. It binds and facilitates the catalytic reaction of arginyl-tRNA synthetase (2,3). Recent studies show that CD23 plays an essential role in the AIMP1-induced immune response and might be a target in the treatment of inflammatory diseases (4).