GABRA6 抗体
Quick Overview for GABRA6 抗体 (ABIN5688947)
抗原
See all GABRA6 抗体适用
宿主
克隆类型
标记
应用范围
-
-
纯化方法
- Affinity Purified
-
免疫原
- GABAA Receptor a6 (CT) polyclonal antibody was raised against a fusion protein with the amino acid sequence representing the cytosolic loop of rat GABAA-R a6 Subunit.
-
-
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (Internal Region) antibody
GABRA6 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (N-Term) antibodyGABRA6 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (Cytoplasmic Domain) antibodyGABRA6 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (Cytoplasmic Loop) antibodyGABRA6 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (AA 20-30) antibodyGABRA6 适用: 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (AA 20-37), (Extracellular) antibodyGABRA6 适用: 大鼠 WB, IHC, IF, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (AA 20-242) antibodyGABRA6 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (AA 15-26) antibodyVerified GABRA6 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
-
-
应用备注
- GABAA Receptor antibody is specific for the 56 to 57k GABAA-R α,6-Subunit in rat brain membrane fractions. Rabbit anti-GABAA Receptor α,6 (CT) does not recognize any other GABAA-R subunits as reactivity is eliminated in α,6 knockout brain. Antibody dilutions and tissue load should be based on tissue type and expected expression level. Initial recommended range of dilutions: 1:1000 to 1:2000. Recognizes bovine, human, mouse and rat GABAA-R-α,6-subunit. Applications include Dot Blots (DB) and Western Blot (WB). Suitability for Immunohistochemistry (IHC) not yet determined. When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- 100 μLin 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
-
储存条件
- -20 °C
-
储存方法
- For long term storage -80°C is recommended, but shorter term storage at -20°C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stable for one year.
-
-
- GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))
-
别名
- GABA A Receptor alpha 6
-
背景
- Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA-Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor. Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABAA-R function.
-
分子量
- 57 kDa
-
基因ID
- 29708
-
UniProt
- P30191
-
途径
- Synaptic Membrane
抗原
-
